getDiseaseAssociatedTargets

Free

Rank the targets (genes) associated with a disease by Open Targets association score (0-1), with the score broken down per evidence type. Pass targetIds to score specific target-disease pairs. Target IDs are Ensembl; use the symbol with chembl-mcp searchTargets for ChEMBL bioactivity data.

Try it

Open in playground

kirha tools run opentargets_getDiseaseAssociatedTargets \
  --input '{
    "diseaseId": "MONDO_0005233"
  }'

Uses the key saved by kirha auth login.

diseaseIdstring, required
EFO/MONDO ID from searchEntities, e.g. MONDO_0005233
includeIndirectboolean, default true
Include evidence propagated from descendant diseases
limitinteger, default 15, 1 to 50
nameFilterstring
Keep targets whose symbol/name contains this text
pageinteger, default 0, 0 to 200
sortBystring, default "overall"
Rank by overall score or by one evidence type, e.g. genetic_association for genetic evidence
One of overall, genetic_association, somatic_mutation, clinical, affected_pathway, literature, animal_model, rna_expression
targetIdsstring[], Up to 50 items
Ensembl gene IDs to restrict to specific pairs